Can a person who is considered wise or knowledgeable still be impacted by ignorance?

Yes, Chapter 50 clearly states that even a wise person can be overcome by ignorance. It provides the powerful example of "a supreme knower like Shuka—even he suffered loss due to doubt (vikalpa)." The text explains that when doubt enters knowledge, it can make a wise person prideful, and this doubt is the source from which ignorance manifests. It uses the analogy of a drop of fermented gruel spoiling a large pot of milk to show how doubt corrupts knowledge. Furthermore, it notes that a person who is 'wise' by worldly standards but remains deluded by attachments to money and family is still operating from a state of ignorance and does not know their own welfare.